On the late shift, a dedicated nurse and a mysterious man encased head to toe in a body cast work to uncover a conspiracy involving the hospital she works at.

SYNOPSIS:

Act 1: John Doe attempts to escape after stealing data but fails and is knocked unconscious. Henchmen Fogg and Glenn dispose of his body to simulate a suicide. At a quiet hospital, nurse Jane tends to hypochondriac patient Jennings and sees news about assistant attorney general Hank Gorman targeting white-collar criminals. John Doe, encased in a body cast, is brought in.

Jane’s friend Zelda leaves for a family emergency, so Jane covers her shift. John knows details about Jane, alarming her. Jane also questions the necessity of a body cast for another patient, Mrs. Smith. Hospital owner Mr. Chester interrogates Fogg and Glenn about John’s disposal, demanding they find him. Jane denies knowing about John Doe to Fogg and Glenn. John begs Jane to cut him out of the cast, but she refuses due to her nursing oath.

Fogg and Glenn discover Jane has John Doe and start searching for them. Jane overhears that they caused John’s injuries. Jennings reveals he helped John escape to the morgue. Jane heads there, but Mr. Chester sends Fogg and Glenn after her. Jane decides to help John escape to save both their lives.

Act 2: Jane and John outwit Fogg and Glenn, escaping down a parking ramp in a wheelchair. They flee in an ambulance, which they later ditch. John reveals foul play at the hospital but needs more information. Jane, needing coffee, detours, and they bond. Mr. Chester duplicates Zelda’s phone, assuming Jane will contact her. He meets with Hank Gorman, who disrespects him while investigating a wealthy patient’s death.

Jane and John visit Boxer, an elderly techie who helps decode the stolen data. They discover Mr. Chester is laundering money through companies he now owns, formerly owned by wealthy patients. Fogg and Glenn attack, but Boxer sacrifices himself to let Jane and John escape. Mr. Chester captures Boxer but decides to kill Fogg and Glenn for their failures.

Hank learns from Zelda that doctors are overdosing patients and excessively using body casts. With information from Brenda Headley, a white-collar criminal, he plans to expose the malpractice. Jane learns John faked his death, and they rush to deliver the data to Hank before he is overdosed. Zelda and Jennings help disrupt the overdose plan, and Hank arrests Mr. Chester.

Hank reveals John is a cyberterrorist who used Jane. Jane struggles with this revelation but decides to rescue John when Jennings tells her he’s being transported offshore. She and Zelda infiltrate the 38th floor, where patients are prepped for body casts, and Jane takes Brenda’s place.

Act 3: Jane wakes up in a body cast on a plane heading to a tropical island resort. At the resort, Mr. Chester is hosting a dinner, celebrating Brenda Headley’s duplication technology. Jane is taken to have her cast removed and discovers Fogg and Glenn are alive. She finds John, Boxer, and John’s parents in the medical quarters. John breaks free and saves them, but Hank reveals he’s working with Mr. Chester. They’ve been duplicating white-collar criminals to serve sentences on the resort while their duplicates are imprisoned.

Jane and Zelda are taken for duplication, but Jane causes a distraction, allowing John and Boxer to hide. John chases Mr. Chester and Hank to the plane but accidentally boards it as it takes off. Jane contacts John via radio before the signal cuts out. Jennings, undercover at the hospital, rescues Jane, Zelda, and John’s parents from the island.

Weeks later, Jane, still upset about losing John, takes her MCATs. Leaving the exam, she glimpses a man in a body cast across the street and smiles, hinting at John’s survival.